Peptide antitumor vaccines targeting HER2/neu

Antitumor vaccines are aimed at correcting cellular immunity by overcoming immunological tolerance with eluding surveillance due to the specific presentation of tumor-associated or tumor-specific antigens immunocompetent cells.The purpose this review was study modern strategies for development antitumor containing epitopes HER2/neu receptors acting as antigens. Approaches creation such classified targeting T-cell link B-cells choice and length used use adjuvants.The provides information on topic, obtained from more than 50 publications last 20 years, found in most significant sources citation. The text is categorized convenience perception scientists different specialties completed a brief conclusion an emphasis prospects. results clinical studies analysis features immunotherapy, mainly breast cancer expression, considered. Vaccines histocompatibility complexes compared. traces evolution vaccine preparations simplest short peptide sequences complex combined systems, including viral vectors. Attention paid various methodological approaches drugs: computer design phage display experiments vitro/in vivo. placed problem personalized approach vaccination oncological patient associated mutation process occurring inside tumors leading appearance unique participation complement system components antibody-mediated lysis tumor cells induced presented discussed.Thus, introduces readers existing directions creating immune drugs designed suppress activating body’s own forces prospect their development.